If you've called Zune support, I suppose they've asked you if you have a supported Windows installation (Win XP with SP2, MCE 2005, Vista) ? Let's assume thats not the problem.
Have you tried installing it from the CD and from the
www.zune.net newer version?
Are you an administrator on that PC?
If you have installed the Zune Software, when your Windows asks you for a Zune driver point it to: c:\Program files\Zune.inf